Y2020_and_earlier

Summary: Thrombin is a serine protease that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with numerous diseases such as atherosclerosis and stroke. To detect thrombosis in living animals, we design nanoparticles to sense the activity of thrombin by producing a signal in urine for detection using standard clinical methods. We show that signals in urine differentiate between healthy and thrombotic states and correlate closely with the aggregate burden of blood clots formed in the lungs. Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases from urine and may allow applications in point-of-care diagnostics.

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis, ACS Nano

Congratulations to my former trainee and newly minted Harvard MD Gaya Murugappan for receiving cum laude honors for her MD thesis! Best of luck at Stanford!

I will be presenting a poster at the HHMI Science Meeting at Janelia Farm on my work on synthetic biomarkers. Should be a week of terrific talks!

Our patent application for our work on synthetic biomarkers has been issued! US patent No: 8,673,267

My PhD colleagues and I have just been awarded a patent for our invention of DNA-encoded pMHC tetramers! U.S. Patent No: 8,394,590

Congrats to my former UROP and current Harvard MD/PhD candidate Omar Abudayyeh for being named a Soros Fellow!

A patent has been granted for my work at Caltech on DNA-encoded Antibody Libraries! US Patent No: 8,354,231