Learn how we synthesize protease nanosensors with our latest JOVE publication
Brandon walks through the synthesis of iron oxide nanosensors in our latest publication in JOVE. Watch the video here.
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Precisely Targeting Tumors with Cancer-Fighting T Cells
Our work on remote control T cells for cancer immunotherapy was recently published in ACS Synthetic Biology! Engineered T cell therapies are a new class of treatments that have the potential to cure patients of cancer. However, tumors have the uncanny ability to turn off T cells to evade being targeted. In our study, we developed a new technique to remotely activate T cells, which were genetically modified, using laser targeting and pulses of heat.
Our study was highlighted by numerous news outlets – read more about this technology below.
ASME: Precisely targeting tumors with cancer fighting T cells
Georgia Tech Research Horizons: Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells
Medical News Today: This ‘genetic switch’ could help fight cancer
Additional coverage by Science Daily, Controlled Environments, Phys.org, EurekAlert!, Nanowerk, Nanotechnology Now, Medgadget
LSI goes abroad: 4th Paris NASH Meeting!
Dr. Kwong traveled to the Institut Pasteur in Paris, France to talk about work from our lab and Glympse Bio at the 4th Paris NASH Meeting. His talk was titled “Protease activity signatures in NASH”.
The Paris NASH Meeting is an international academic meeting is aimed to do a deep-dive into many aspects of NASH and to deliver scientific innovations that are not covered in other meetings.
Kevin Tao and Lee-Kai Sun win undergraduate research awards
Congratulations to Kevin and Lee-Kai for winning awards from the Alfred H. Gibeling Family Research Fund through the Biomedical Engineering department to conduct undergraduate research!
Dr. Kwong awarded new patent
Dr. Gabe Kwong at GT/Emory and Dr. Sangeeta Bhatia at MIT have been granted a patent on using isotope-encoded reporters for multiplexed detection of target analytes in biological samples. Congrats! Read more about the patent here.
LSI chosen to give plenary talk at American Transplant Congress 2018
Work in our lab on using synthetic biomarkers to noninvasively detect the onset of acute transplant rejection, spearheaded by graduate student Quoc Mac, was chosen as a plenary talk at the 2018 American Transplant Congress in Seattle, WA. We are excited to share our technology with scientists and clinicians around the country and world!
ATC 2018 is a joint meeting of the American Society of Transplant Surgeons (ASTS) and the American Society of Transplantation (AST), bringing together nearly 5,000 attendees and exhibitors—a diverse mix of physicians, surgeons, scientists, nurses, organ procurement personnel, advanced transplant providers, pharmacists, administrators, and other transplant professionals. The five-day event features nearly 1,800 abstracts, 500+ oral presentations, and more than 1,200 poster presentations, all delivered in a way that encourages the exchange of new clinical and scientific information and supports an interchange of opinions regarding care management and socioeconomic, ethical, and regulatory issues relevant to organ and tissue transplantation.
Kevin Tao and Lee-Kai Sun win PURA Salary Awards
Congratulations to Kevin and Lee-Kai for winning a President’s Undergraduate Research Awards (PURA) for Fall 2018! PURA fund student salaries to conduct undergraduate research with Georgia Tech faculty and offset travel expenses for undergraduates to present their research at professional conferences. Between two hundred and three hundred competitive awards are offered on campus each year. Read more about PURA here.
Brandon Holt awarded NSF Graduate Fellowship
Congratulations to Brandon for winning a NSF Graduate Fellowship! The NSF Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines.
Remote control using heat-triggered gene switches published in ACS Synthetic Biology
Our work on engineering thermal gene switches for spatial and remote control of transcriptional activity in mammalian cells using pulses of heat was published in ACS Synthetic Biology! Congrats to Ian and the team!
Read the entire manuscript here.
| Summary | Genetically engineered T cells have the potential to cure patients of cancer. Yet after they are infused into recipients, we lack the ability to control their activity throughout the body including at disease sites. Here we genetically engineer T cells to allow them to be remotely controlled using pulses of heat localized by laser light. This could improve the precision of T cell therapies for cancer. |
| Press Coverage | Georgia Tech Research Horizons “Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells” | ASME “Precisely targeting tumors with cancer fighting T cells” | Medical News Today “This ‘genetic switch’ could help fight cancer” | Science Daily | Controlled Environments | Phys.org | EurekAlert! | Nanowerk | Nanotechnology Now | Medgadget “Remote-controlled signal activates T cells for cancer immunotherapy” |
Anna Romanov wins PURA Salary Award
Congratulations to Anna for winning a President’s Undergraduate Research Award (PURA) for Summer 2018! PURA fund student salaries to conduct undergraduate research with Georgia Tech faculty and offset travel expenses for undergraduates to present their research at professional conferences. Between two hundred and three hundred competitive awards are offered on campus each year. Read more about PURA here.