Our work on engineering biological circuits was published in Nature Communications! Congratulations to Brandon and the team! Read the full manuscript here.
Summary | Biological circuits with the ability to automatically control therapeutic responses present a new leap forward in the field of programmable medicine. Yet most biocircuits to date rely on gene expression, which is relatively slow (~minutes) compared to enzyme activity (~milliseconds). Here we explore the use of protease enzymes as the foundation of activity based biocircuits. This could add a new tool to the arsenal of programmable medicine.