Protease circuits for processing biological information published in Nature Communications

Our work on engineering biological circuits was published in Nature Communications! Congratulations to Brandon and the team! Read the full manuscript here.

Summary | Biological circuits with the ability to automatically control therapeutic responses present a new leap forward in the field of programmable medicine. Yet most biocircuits to date rely on gene expression, which is relatively slow (~minutes) compared to enzyme activity (~milliseconds). Here we explore the use of protease enzymes as the foundation of activity based biocircuits. This could add a new tool to the arsenal of programmable medicine.