Our work on engineering CAR T cells to turn on and fight cancer in response to localized heat was published in Nature Biomedical Engineering! Congratulations to Ian, Ali, and the team! Read the full manuscript here.
Summary | Treating solid tumors with chimeric antigen receptor (CAR) T cells typically results in poor responses. In this study, we developed a new class of CAR T cells that are switched on by localized heating to release potent biologics that are otherwise too toxic to use systemically. Thermal targeting of CAR T cells opens the door for spatial control to potentiate cancer therapy.
Press Coverage | Georgia Tech Research Horizons “Heat-controllable CAR T-cells destroy tumors and prevent relapse in new study” | TheScientist “Heating up CAR T cells for cancer therapy” | GEN “CAR T gets hot under the collar for cancer targets” | Mirage News | Newswise | MedicalXpress | The Medical News | Technology Networks | AZO Life Sciences | Front Line Genomics | Science Daily