AND-gated protease nanosensors to detect anti-tumor immunity published in Nature Nanotechnology

Our work on AND-gated protease-activated nanosensors to improve precision for detection of anti-tumor immunity versus resistant tumors and off-tumor anti-viral responses was published in Nature Nanotechnology! Congratulations to Anirudh and the team! Read the full manuscript here.

Summary | Synthetic biology is paving the way for more precise cancer diagnostics by programming biocircuits that perform logical functions. While most advances to date rely on genetic engineering of living cells, cell- and gene-free biocircuits are gaining attention for their potential to lower barriers for clinical translation. We developed a new cell- and gene-free design of AND-gated nanosensors that detect activity from a pair of proteases to sense therapeutic anti-tumor immune responses with higher precision. In preclinical studies, we demonstrated that AND-gated nanosensors can selectively detect anti-tumor responses during immune checkpoint blockade therapy while minimizing activation from off-tumor anti-viral immunity in the lungs.

Press Coverage | Georgia Tech Research “New Biosensors Could Revolutionize Cancer Detection” | Mirage News | Phys.org