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LSI members present at BMES 2023

Congratulations to these students who presented their work at the 2023 BMES Annual Meeting in Seattle, WA:

Ida Su – “Engineering virus-specific T cells in vivo for CAR T cell therapy”

Ali Zamat – “Remote activation of CAR T cells by MR-guided focused ultrasound for treatment of brain tumors”

Aaron Silva – “DNA-gated Cytometry for Scarless Isolation of Antigen-specific T cells”

Chloé Thiveaud – “Lipid nanoparticle delivery of synthetic antigens to sensitize solid tumors to CAR-mediated cytotoxicity”

Anirudh Sivakumar – “Monitoring immune dynamics in the tumor microenvironment via AND-gated protease sensors”

Aaron and Chloé present at Cell and Tissue Engineering Symposium

PhD students Aaron Silva and Chloé Thiveaud presented posters and gave rapid-fire talks at Georgia Tech’s first-ever Cell and Tissue Engineering Symposium as part of the Cell and Tissue Engineering Training Grant. Congrats to both of them!

Aaron Silva – “DNA-gated Cytometry for Scarless Isolation of Antigen-specific T cells”

Chloé Thiveaud – “Lipid nanoparticle delivery of synthetic antigens to sensitize solid tumors to CAR-mediated cytotoxicity”

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LSI members present at BMES 2021

Congratulations to these students who presented their work at the 2021 BMES Annual Meeting in Orlando, Florida:

Ida Su – “In situ programming of virus-specific T cells for CAR T cell therapy”

Lena Gamboa – “Sensitizing Solid tumors to T cell Mediated Immunity Using Synthetic Antigens as CAR Targets”

Ali Zamat – “Thermal Control of Bispecific T Cell Engagers Mitigates Tumor Escape by CAR T Cells”

LSI goes to BMES 2020

Congratulations to these students who delivered podium talks at the 2020 BMES Virtual Annual Meeting:

Quoc Mac – “Activity Sensors for Monitoring Therapeutic Response and Illuminating Resistance Mechanisms during Immune Checkpoint Immunotherapy”

Lena Gamboa – “Sensitizing solid tumors to CAR T cell-mediated cytotoxicity using synthetic antigens”

Anirudh Sivakumar – “Logic-Gated Protease Sensors for Non-Invasive Monitoring of Immune Checkpoint Blockade Therapy”

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Ian Miller presents work at Keystone Symposium

Ian Miller presents work at Keystone Symposium

Ian traveled to Banff, Canada to present his work at a poster presentation at the “Emerging Cellular Therapies: Cancer and Beyond” Keystone Symposium.

Meeting Summary: After many years of fundamental research, cell-based therapies are now recognized as effective medicines for treatment of a specific subset of cancers as well as a growing list of autoimmune, degenerative and infectious diseases. This clinical progress has been propelled by exponential growth in understanding of the underlying cell biology, and increasingly sophisticated techniques for genetic engineering and for using synthetic biology to control cellular therapeutics. Cellular therapeutics are now poised for increasing impact both in cancer medicine and in the treatment of genetic, autoimmune and degenerative diseases. This conference will bring together fundamental researchers and translational scientists to discuss recent successes and highlight challenges across the spectrum of emerging cellular therapeutics.

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Ian presents at Fred Hutch Cancer Center, Seattle

Ian presents at Fred Hutch Cancer Center, Seattle

Grad student Ian Miller presented his work on thermal control of CAR T cells at the Fred Hutch Immuno-Oncology Graduate Student Symposium hosted by Fred Hutch’s Immunotherapy Integrated Research Center (IIRC). Participants were able to meet faculty, learn about the breadth of research done in immuno-oncology, visit research laboratories and shared resource facilities, and tour Fred Hutch’s Bezos Family Immunotherapy Clinic at the Seattle Cancer Care Alliance.

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Dr. Kwong delivers invited lecture at Transplant Immunosuppression 2019

Dr. Kwong was invited to speak at the Transplant Immunosuppression 2019 Conference in Minneapolis, MN. The course focused on current options for immunosuppression (and what’s in the pipeline), with particular attention to individualization of immunosuppression based on clinical and/or laboratory parameters; prevention, diagnosis and treatment of antibody-mediated rejection; improving long-term transplant outcomes; and major issues in transplant-related infectious disease, living donation, and patient-centered care.

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LSI awarded talks at BMES 2019

LSI awarded talks at BMES 2019

Multiple students were awarded podium talks at the 2019 BMES Annual Meeting in Philadelphia, PA. They are:

Brandon Holt – “Synthetic biological circuits for treating prodrug-resistant bacteria”

Brandon Holt – “Proteases as biological bits for programmable medicine”

Ian Miller – “Remote Control of CAR T Cells Using Thermal Cues”

Shreyas Dahotre – “Ultrasensitive Detection of Protein and Cellular Biomarkers by CRISPR-Cas12a”

Lena Gamboa – “Heat-triggered CRISPR-dCas9 for the remote control of therapeutic T cells”

Quoc Mac – “Activity Therasensors for Predictive Monitoring of Response to Checkpoint Blockade Immunotherapy”

Lee-Kai Sun – “Designing Synthetic Gene Switches for Single-cue Thermal Control of Engineered T Cells”

Anna Romanov – “Precise T Cell Drug Delivery Using pMHC Liposomes”

Look forward to seeing you in Philly!

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Dr. Kwong part of NCI Think Tank discussing early cancer detection

Dr. Kwong part of NCI Think Tank discussing early cancer detection

Dr. Kwong was invited to participate in the Synthetic Biomarkers for Detection of Cancers at Incipient and Early Stages (SYNDICATE) Think Tank Meeting hosted by the Division of Cancer Prevention (DCP) at the National Cancer Institute (NCI), and co-chaired by Dr. Sangeeta Bhatia, Massachusetts Institute of Technology, and Dr. Sam Gambhir, Stanford University.

The think tank brought together experts in the biomarker community to review the current status of synthetic biomarkers and discuss the challenges in development of biomarkers, to discuss translation of promising synthetic tools safely from preclinical models to humans and the development of new tools, to explore combination with endogenous biomarkers, as well as use as companion diagnostics, patient safety, and a variety of other pertinent topics.

Learn more about the meeting here.

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Lena Gamboa presents work at Synthims 2019

Lena Gamboa presents work at Synthims 2019

Lena traveled to Ascona, Switzerland to present her talk “Heat-triggered CRISPR-dCas9 for the remote control of therapeutic T cells” at Synthims 2019.

The conference covered insights in therapeutic protein engineering, rational vaccine design and delivery; advances in single-cell sequencing and microfluidics as related to the adaptive immune system; adoptive immune cell transfer therapies; and cancer immunotherapy and infectious diseases.

 

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