Journal Publications

Show images < 2014 2015 2016 2017 2018 2019

Full citation data: Pubmed, Web of Science, Google Scholar

† equal contribution

  1. Gamboa L, Zamat A, and Kwong GA, "Synthetic immunity by remote control" under review.
  2. Tadros A, Romanyuk A, Miller IC, Santiago A, Noel R, O'Farrell L, Kwong GA, and Prausnitz, "STAR particles for enhanced topical drug and vaccine delivery" under review.
  3. Holt BA, Curro I, and Kwong GA, "Prodrug defiance reveals logic-based strategies to treat bacterial resistance" under review.
  4. Gamboa L, Phung EV, Li H, Meyers JP, and Kwong GA, "Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation" under revision.
  5. Holt BA and Kwong GA, "Proteases as biological bits for programmable medicine" under revision.
  6. Zhuang Q, Holt BA, Kwong GA, and Qiu Peng, "Deconvolving multiplexed protease signatures with substrate reduction and activity clustering" PLoS Comput Biol, 15(9): e1006909 (2019). [DOI: 10.1371/journal.pcbi.1006909]
  7. Mac QD†, Mathews DV†, Kahla JA, Stoffers C, Delmas OM, Holt BA, Adams AB‡ and Kwong GA‡, "Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity" Nat Biomed Eng. 3, 281–291 (2019). [DOI: 10.1038/s41551-019-0358-7]
  8. Dahotre SN, Chang YM, Romanov AM and Kwong GA, "DNA-barcoded pMHC tetramers for detection of single antigen-specific T cells by digital PCR" Anal. Chem.  91(4), 2695–2700 (2019). [DOI: 10.1021/acs.analchem.8b04153]
  1. Holt BA, Mac QD and Kwong GA, "Nanosensors to detect protease activity in vivo for noninvasive diagnostics" J. Vis. Exp. (130), e37937, (2018). [DOI: 10.3791/57937]
  2. Miller IC, Gamboa Castro M, Maenza J, Weis JP and Kwong GA, "Remote control of mammalian cells with heat-triggered gene switches and photothermal pulse trains" ACS Synth. Biol. 7(4) 1167–1173 (2018). [DOI: 10.1021/acssynbio.7b00455]
  3. Dahotre SN, Chang YM, Wieland A, Stammen SR and Kwong GA, "Individually addressable and dynamic DNA gates for multiplexed cell sorting" Proc. Natl. Acad. Sci. USA 115(17) 4357–4362 (2018). [DOI: 10.1073/pnas.1714820115]
  1. Dudani JS, Buss CG, Akana RTK, Kwong GA and Bhatia SN, "Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts" Adv. Funct. Mater. 26(17), 2919–2928 (2016). [DOI: 10.1002/adfm.201505142]adfm201505142-gra-0001-m
  1. Dudani JS, Jain PK, Kwong GA, Stevens KR and Bhatia SN, "Photoactivated spatiotemporally-responsive nanosensors of in vivo protease activity" ACS Nano 9(12), 11708–11717 (2015). [DOI: 10.1021/acsnano.5b05946]Dudani ACS nano
  2. Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat MS and Bhatia SN, "Mathematical framework for activity-based cancer biomarkers" Proc. Natl. Acad. Sci. USA 112(41), 12627–12632 (2015). [DOI: 10.1073/pnas.1506925112]Kwong PNAS 2015
  3. Danino T†, Prindle A†, Kwong GA, Skalak M, Li H, Allen K, Hasty J and Bhatia SN, "Programmable probiotics for detection of cancer in urine" Sci. Transl. Med. 7(289), 289ra84 (2015). [DOI: 10.1126/scitranslmed.aaa3519]Probiotic paper
2014 & Earlier 
  1. Warren AD, Gaylord ST, Ngan KC, Milutinovic MD, Kwong GA, Bhatia SN and Walt DR, "Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers" J. Am. Chem. Soc. 136(39), 13709–13714 (2014). [DOI: 10.1021/ja505676h] Warren JACS 2014 TOC Fig
  2. Lin KY, Lo JH, Consul N, Kwong GA and Bhatia SN, "Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade" ACS Nano 8(9), 8776–8785 (2014). [DOI: 10.1021/nn501129q]Nanostat TOC fig
  3. Warren AD†, Kwong GA†, Wood DK†, Lin KY and Bhatia SN, “Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics" Proc. Natl. Acad. Sci. USA 1119(10), 3671–3676 (2014). [DOI: 10.1073/pnas.131465111]
  4. Lin KY†, Kwong GA†, Warren AD, Wood DK and Bhatia SN, “Nanoparticles that sense thrombin activity as synthetic biomarkers of thrombosis" ACS Nano 7(10), 9001–9009 (2013). [DOI: 10.1021/nn403550c]
  5. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov D, Liu SB, Warren AD, Popov Y, Schuppan D and Bhatia SN,  “Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease” Nat. Biotechnol. 31, 63–70 (2013). [DOI: 10.1038/nbt.2464]
  6. Millward SW, Henning R, Kwong GA, Pitram S, Agnew HD, Deyle KM, Nag A, Hein J, Lee SS, Lim J, Pfeilsticker JA, Sharpless KB and Heath JR, “Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1” J. Am. Chem. Soc. 133, 18280–88 (2011). [DOI: 10.1021/ja2064389]
  7. Vermesh U†, Vermesh O†, Wang J, Kwong GA, Ma C, Hwang K and Heath JR, “High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications” Angew. Chem. 50, 7378–80 (2011). [DOI: 10.1002/anie.201102249]
  8. Ma C, Fan R, Ahmad H, Shi Q, Comin-Anduix B, Chodon T, Koya R, Liu C, Kwong GA, Radu C, Ribas A and Heath JR, “A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells” Nat. Med. 17, 738–43 (2011). [DOI: 10.1038/nm.2375]
  9. Kwong GA, Radu CG, Shu J, Koya R, Comin-Anduix B, Hadrup S, Bailey RC, Witte ON, Schumacher TN, Ribas A and Heath JR, “Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific lymphocytes” J. Am. Chem. Soc. 131(28), 9695-703 (2009). [DOI: 10.1021/ja9006707]
  10. Fan R, Vermesh O, Srivastava A, Yen B, Qin L, Ahmad H, Kwong GA, Liu C, Gould J, Hood L and Heath JR, “Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood” Nat. Biotechnol. 26(12), 1373–8 (2008). [DOI: 10.1038/nbt.1507]
  11. Bailey RC, Kwong GA, Radu CG, Witte ON and Heath JR, “DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins” J. Am. Chem. Soc. 129(7), 1959–67 (2007). [DOI: 10.1021/ja065930i]
  12. Bunimovich Y, Shin Y, Yeo W, Amori M, Kwong GA and Heath JR, “Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solutions” J. Am. Chem. Soc. 128(50), 16323–31 (2006). [DOI: 10.1021/ja065923u]


  1. Application No. 62/627,441: "Methods for multiplexed cell isolation using DNA gates" Dahotre S and Kwong GA.
  2. Provisional Patent Application No. 62/403,790: "Remote control of engineered T cell therapies" Miller IC, Gamboa Castro M, and Kwong GA.
  3. Application No. 62/400,656: "Methods and compositions for noninvasive detection of organ transplant rejection" Mac QD, Mathews DV, Adams AB and Kwong GA.
  4. Application No. 62/332,096: "Methods and uses for remotely triggered protease activity measurements" Dudani JS, Schurle S, Jain PK, Kwong GA and Bhatia SN.
  5. Application No. 61/832,766: "Affinity-based detection of ligand-encoded synthetic biomarkers" Kwong GA, Wood DK, Warren AD and Bhatia SN.
  6. Application No. 61/831,916: "Stimulus responsive nanocomplexes and methods of use thereof" Lin KY, Kwong GA, Low JH and Bhatia SN.
  7. Application No. 61/452,908: "Multiplexed detection with isotope-coded reporters" Kwong GA and Bhatia SN.
  8. US Patent No. 8,673,267: "Methods and products for in vivo enzyme profiling" von Maltzahn G, Kwong GA and Bhatia SN. [link]
  9. US Patent No. 8,394,590: "Capture agents and related methods and systems for detecting and/or sorting targets" Kwong GA, Heath JR, Radu CG, Ribas A and Witte ON. [link]
  10. US Patent No. 8,354,231: "Methods and systems for detecting and/or sorting targets" Kwong GA, Bailey RC, Fan R and Heath JR. [link]