Journal Publications

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† equal contribution | ‡ co-corresponding author

    1. Cazanave SC, Warren AD, Pacula M, Touti F, Zagorska A, Gural N, Huang EK, Sherman S, Cheema M, Ibarra S, Serer A, Bates J, Billin AN, Liles JT, Budas GR, Breckenridge DG, Tiniakos D, Ratziu V, Daly AK, Govaere O, Anstee QM, Gelrud L, Luther J, Chung RT, Corey KE, Winckler W, Bhatia SN, and Kwong GA, “Noninvasive urinary monitoring of non-alcoholic steatohepatitis by mass barcoded activity-based sensors” under review.  

    2. Turner TC†, Sok MCP†, Hymel LA†, Pittman F, York WY, Mac QD, Vishna S, Lim HS, Kwong GA, Qiu P, and Botchwey EA, “Harnessing lipid signaling pathways to target specialized pro-angiogenic neutrophil subsets for regenerative immunotherapy” under review.
    3. Miller IC, Sun LK, Harris AM, Gamboa L, Zamat A and Kwong GA, “Remote control of CAR T cell therapies by thermal targeting” biorxiv 062703 preprint.
    4. Holt BA, Curro I and Kwong GA, “Prodrug defiance reveals logic-based strategies to treat bacterial resistance” under review.
    5. Holt BA and Kwong GA, “Protease circuits for processing biological information” Nat. Commun. in press. 
    6. Gamboa L, Zamat A and Kwong GA, “Synthetic immunity by remote control” Theranostics 10(8): 3652–3667 (2020). [DOI: 10.7150/thno.41305]
    7. Kwong GA, “Macrophage sensors for early cancer detection” Clin. Chem. 66(2), 268–270 (2020). [DOI: 10.1093/clinchem/hvz017]
    8. Tadros AR, Romanyuk A, Miller IC, Santiago A, Noel RK, O’Farrell L, Kwong GA and Prausnitz MR, “STAR particles for enhanced topical drug and vaccine delivery” Nat. Med. 26, 341–347 (2020). [DOI:10.1038/s41591-020-0787-6]
    9. Gamboa L, Phung EV, Li H, Meyers JP, Miller IC and Kwong GA, “Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation” ACS Chem. Biol. 15(2), 533–542 (2020). [DOI: 10.1021/acschembio.9b01005]
    Summary | CRISPR-based approaches have achieved wide success in modulating gene activity to control cell function and are potential tools for clinical therapies. However, the lack of precise methods to deliver and control Cas protein expression in vivo remains a critical hurdle. Here we develop a tunable, heat-triggered platform that regulates mammalian cell transcription by remote control of dCas9 transcriptional modulators.   

    1. Dudani JS, Buss CG, Akana RTK, Kwong GA and Bhatia SN, “Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts” Adv. Funct. Mater. 26(17), 2919–2928 (2016). [DOI: 10.1002/adfm.201505142]
    1. Dudani JS, Jain PK, Kwong GA, Stevens KR and Bhatia SN, “Photoactivated spatiotemporally-responsive nanosensors of in vivo protease activity” ACS Nano 9(12), 11708–11717 (2015). [DOI: 10.1021/acsnano.5b05946]
    2. Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat MS and Bhatia SN, “Mathematical framework for activity-based cancer biomarkers” Proc. Natl. Acad. Sci. USA 112(41), 12627–12632 (2015). [DOI: 10.1073/pnas.1506925112]
    3. Danino T, Prindle AKwong GA, Skalak M, Li H, Allen K, Hasty J and Bhatia SN, “Programmable probiotics for detection of cancer in urine” Sci. Transl. Med. 7(289), 289ra84 (2015). [DOI: 10.1126/scitranslmed.aaa3519]