Urine tests for organ transplant rejection

Our work on activity sensors for early and noninvasive detection of acute transplant rejection was just published in Nature Biomedical Engineering! Organ transplantation is the only effective therapy for end-stage organ diseases, yet a key barrier to successful transplantation is acute transplant rejection, in which host immune cells, predominantly T cells, recognize and destroy the foreign transplant. Detecting the onset of acute rejection is crucial for the long-term health and survival of transplant recipients. Currently, the core biopsy remains the diagnostic “gold” standard despite its invasiveness, risk of morbidity, and limited predictive power. Our nanosensors noninvasively monitor the dysregulated states of the immune system to predict the onset of rejection.

Read more about our work here

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